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NAMPT Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NAMPT (26) Apoptosis (4) Autophagy (4) Caspase (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) Drug-Linker Conjugates for ADC (2) GLUT (1) HDAC (2) Indoleamine 2,3-Dioxygenase (IDO) (1) PAK (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (28) Inflammation/Immunology (1) Metabolic Disease (1)

Targets Recommended: NAMPT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112616

NAMPT inhibitor-linker 2	NAMPT Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an *NAMPT* inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC₅₀s of <7 pM and 40 pM, respectively.

HY-112615

NAMPT inhibitor-linker 1	Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an *NAMPT* inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC₅₀s of <3 pM and 9 pM, respectively.

HY-12971

Nampt-IN-1 1 Publications Verification LSN3154567	NAMPT	Cancer
Nampt-IN-1 (LSN3154567) is a potent and selective *NAMPT* inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC₅₀ of 3.1 nM.

HY-161051

Anticancer agent 177	NAMPT DNA Alkylator/Crosslinker	Cancer
Anticancer agent 177 (Compound 11b) is a *NAMPT* inhibitor and DNA alkylating agent. Anticancer agent 177 has antitumor activity in vitro and in vivo .

HY-147838

Nampt-IN-9

NAMPT Cancer

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research .

Nampt-IN-9	NAMPT	Cancer
Nampt-IN-9 (Compound 8) is a potent *NAMPT* inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research .

HY-147795

Nampt-IN-8	NAMPT Apoptosis Reactive Oxygen Species	Cancer
Nampt-IN-8 (Compound 10d) is an *NAMPT* inhibitor with an IC₅₀ of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS .

HY-155506

NAMPT degrader-3	NAMPT	Cancer
NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation .

HY-15766

GNE-617 5+ Cited Publications	NAMPT	Metabolic Disease Cancer
GNE-617 is a specific *NAMPT* inhibitor that inhibits the biochemical activity of NAMPT with an IC₅₀ of 5 nM and exhibits efficacy in xenograft models of cancer.

HY-15766A

GNE-617 hydrochloride 5+ Cited Publications	NAMPT	Cancer
GNE-617 hydrochloride is a specific *NAMPT* inhibitor that inhibits the biochemical activity of NAMPT with an IC₅₀ of 5 nM and exhibits efficacy in xenograft models of cancer.

HY-147193

Nampt-IN-10 TFA	NAMPT	Cancer
Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase *(NAMPT)* inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC₅₀s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs .

HY-147193A

Nampt-IN-10 trihydrochloride	NAMPT	Cancer
Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC₅₀ values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC) .

HY-108701

Nampt-IN-3	NAMPT HDAC Autophagy Apoptosis	Cancer
Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC₅₀s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death .

HY-130606

Nampt-IN-5	NAMPT Cytochrome P450	Cancer
Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC₅₀s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively .

HY-162124

HDAC/NAMPT-IN-1

NAMPT HDAC Cancer

HDAC/NAMPT-IN-1 (compound 39h) is a dual inhibitor of HDAC and NAMPT with IC₅₀ values of 0.72-37081 nM and 1618 nM .

HDAC/NAMPT-IN-1	NAMPT HDAC	Cancer
HDAC/NAMPT-IN-1 (compound 39h) is a dual inhibitor of HDAC and *NAMPT* with IC₅₀ values of 0.72-37081 nM and 1618 nM .

HY-147756

Nampt-IN-7	NAMPT	Cancer
Nampt-IN-7 (compound GF8) is a potent *NAMPT* inhibitor, with an IC₅₀ of 7.31 μM. Nampt-IN-7 also displays cytotoxic activity against human HepG2 hepatocellular carcinoma cell line with an IC₅₀ of 24.28 μM .

HY-148572

NAMPT/IDO1-IN-1	Indoleamine 2,3-Dioxygenase (IDO) NAMPT	Cancer
NAMPT/IDO1-IN-1 is an orally active dual inhibitor of *NAMPT* and IDO1 with IC₅₀s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel .

HY-50876

(E)-Daporinad Maximum Cited Publications 34 Publications Verification FK866; APO866	NAMPT Autophagy	Cancer
(E)-Daporinad (FK866) is an effective inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with an IC₅₀ of 0.09 nM.

HY-161180

Antitumor agent-136	NAMPT	Cancer
Antitumor Agent-136 (Compound 17) is a potent broad-spectrum antitumor agent and a *NAMPT* inhibitor with an IC₅₀ of 9.5 nM. Antitumor Agent-136 can reduce the levels of intracellular and extracellular *NAMPT* protein through the ubiquitin proteasome pathway, thus achieving tumor inhibition .

HY-12808

STF-118804

1 Publications Verification

NAMPT Apoptosis Cancer

STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.
HY-101280

LB-60-OF61

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines .

STF-118804 1 Publications Verification	NAMPT Apoptosis	Cancer
STF-118804 is a highly specific *NAMPT* inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.

LB-60-OF61
LB-60-OF61 is a *NAMPT* inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines .

HY-12793

Padnarsertib 1 Publications Verification KPT-9274	PAK NAMPT	Cancer
Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC₅₀s of <100 nM and 120 nM, respectively .

HY-101280A

LB-60-OF61 hydrochloride	NAMPT	Cancer
LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines .

HY-14373

CB30865 ZM 242421	NAMPT	Cancer
CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range) .

HY-12628

GNE-618 1 Publications Verification	NAMPT	Cancer
GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC₅₀ of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity .

HY-18728

STF-31 10+ Cited Publications	GLUT Autophagy	Cancer
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1 μM. STF-31 is also a *NAMPT* inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells .

HY-10079

CHS-828 GMX1778	NAMPT Apoptosis	Cancer
CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC₅₀ less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD ⁺ and exhibits a potent anticancer activity .

HY-10080

Teglarinad chloride GMX1777; EB-1627	NAMPT	Cancer
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .

HY-136241

OT-82	NAMPT Caspase	Cancer
OT-82 is a potent, selective and orally active inhibitor of *NAMPT. OT-82 is selectively toxic to cells of hematopoietic origin and induces cell death in a NAD ⁺ dependent manner. OT-82 is a promising antineoplastic agent* for the study of hematological malignancies .

HY-14374

GPP78 1 Publications Verification CAY10618	NAMPT Autophagy	Inflammation/Immunology Cancer
GPP78 (CAY10618) is a potent *Nampt* inhibitor with an IC₅₀ of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC₅₀ of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects .

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NAMPT Inhibitor

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